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SARMS, or Selective Androgen Receptor Modulators, offer the benefits of traditional anabolic androgenic steroids such as testosterone (including increased muscle mass, fat loss, and bone density), all the while giving the user little to no unwanted side effects that come with steroids.
SARMS are not new - they have been around for over 10 years. However, they are a unique class of compound currently undergoing investigation and development from a number of pharmaceutical companies. SARMs are advertised as safer, legal alternatives to anabolic androgenic steroids. They are said to provide similar positive results, but to have a lower risk of side effects.
Note that some similar experimental drugs (such as Cardarine/GW-501516, Ibutamoren/ MK-677, and YK11) are sometimes marketed as SARMS - they aren’t but are still sometimes incorporated into SARM stacks.
There are a number of different types of SARMS available.
Nutrobal (MK-677) is a chemical that has the characteristics of Human Growth Hormone (HGH). It is an orally active growth hormone secretagogue. A secretagogue causes substances to be secreted. MK677 has thisability because of its ability to mimic the GH stimulating action of a hormone called ghrelin. Ghrelin is categorized as a peptide, and is commonly referred to as “the hunger hormone,” which explains the drastic rise in appetite with 677 use. Ghrelin plays a large role in regulating the distribution and the rate of energy use. It is imperative to understand all of these concepts to decipher the many capabilities that 677 has. mk677 can not only increase plasma levels of many types of hormone, but also provide sustainable increases. These are long term and not just “for the time being” types of increases. Studies show that Nutrobal can increase muscle mass and bone mineral density, as well as altering the metabolism of body fat, possibly becoming a treatment for obesity.
Nutrobal (MK-677) studies have been conducted since the late 90s. There is a wide array of benefits that have been found with use. The main benefit that consistently shows in studies is the increase in growth hormone and IGF-levels provided with use. These have shown significant increases in regards to both. Below is a list of other significant benefits found through studies and implementation on humans:
It is evident by the list of benefits that MK677 is highly desirable. These benefits, in conjunction with the very small chance of side effects show MK677 to be a breakthrough drug.
As stated above, MK677 carries little to no side effects. However, it is always important to understand the possibilities that could occur with use.
The main side effect associated with MK677 is the increase in appetite, which may be welcomed by many research subjects. Studies show this to subside after 4-8 weeks, though this varies from person to person. The other side effects that showed, though were very infrequent and uncommon, were mild lower extremity edema and muscle pain.
Secretagogues generally carry the worry of prolactin increase. However, studies with MK677 did not show any increase in prolactin levels. Cortisol levels were not increased in studies either. These traits make Nutrobal stand out amongst other chemicals that attempt to work in the same manner but carry these unwanted side effects.
Studies conducted had a dosage of between 5-25 mg per day, with 25 mg being the most common and effective dose. MK677 has a 24 hour half life and showed to be best tolerated by rats when fed to them each morning on an empty stomach. MK677 has extreme benefits in regards to helping with a deeper sleep. However, it can interfere with sleep patterns if taken too late at night or too close to bedtime. MK677 can be used continuously for 1-2 years with no concern of an individual becoming desensitised to it.
Ostarine (MK2866) is classified as a SARM. It was initially developed to treat and prevent muscle wastage amongst cancer and osteoporosis patients. It has been considered and hoped to be used for preventing muscle atrophy, cachexia and sarcopnia, and has also been discussed for use during TRT/HRT.
Ostarine binds to the AR (androgen receptor), which demonstrates anabolic activity in the bone and muscle. MK allows for muscle growth by finding and activating the AR. By binding to the AR, MK increases protein synthesis and alters the expression of genes.
MK2866 almost exclusively exerts its anabolic effects on muscle tissue and minimizes muscle atrophy, most notably during recovery periods from surgeries and injuries. This makes MK useful and desirable in numerous instances. MK is highly effective at gaining and/or maintaining extremely lean body mass.
One of the major benefits of Ostarine use is its healing benefits. These benefits translate into anabolism of the both the bone and skeletal tissues. Research has shown that these effects allow it to be used in a variety of ways, most notably in the treatment of osteoporosis and muscle wasting. It is also a strong compliment to other treatments thattreat bone density reduction. MK has extremely strong benefits when used for injury rehabilitation. MK provides REAL healing as opposed to methods that act as a band aid, providing temporary relief and only masking the injury. MK actually heals an injury at a rapid rate.
SARMS do not aromatize, conferring all their effects to AR binding and not to metabolic conversion to active androgens/estrogens. There have been rare circumstances in blood work from research subjects showing slightly elevated estradiol levels (which correlates with its effectiveness in treating bone, tendon and ligament injuries). These rare circumstances have only shown small and slight increases and are not a cause for concern, but even so, individuals should be aware of the small possibility. When there is concern of estrogen issues occurring, it is always wise to have an aromatase inhibitor, such as aromasin or arimidex, on hand in case treatment is necessary.
MK-2866 can be slightly suppressive when exceeding 4 weeks of usage. This suppression has shown to be extremely minimal and no cause for concern or worry. A strong test booster can be used in conjunction with MK to ensure less than minimal amounts of suppression occurs. A 3-4 week mini post cycle therapy protocol is all that is need after use. Recovery time takes 2-3 weeks.
The dosage depends on your goals. Ostarine can be taken by men, women, and individuals looking to treat bone issues like Osteoporosis.
The most commonly used dosage by bodybuilders is 25mg. The range for men is 20- 35mg, with the higher dose being used by men over 200lbs that are bulking. A dose around 15mg daily is used for cutting cycles.
Women and people with bone issues should take 10-15mg daily.
Ostarine has a 24 hour half life, so it’s unnecessary to split up your daily dose. This is much easier than having to space out and remember when to take your dose every day.
(LGD-4033) is categorized as a SARM. LGD has the capability to bind to the AR (androgen receptor) with an extremely high affinity. LGD is generally classified as an ARligand that is tissue selective. It was originally developed to treat muscle wasting in cancer patients, age-related muscle loss, as well as acute and chronic illness.
(LGD-4033) can produce the therapeutic benefits of testosterone but in a far safer way. This is due to its tissue-selective mechanism of action in conjunction with oral administration. It also contains the ability to bring about anabolic activity in muscles, anti-resorptive and anabolic activity in bones, as well as a selectivity for muscle and bone versus prostate and sebaceous glands.
LGD has also shown to have strong healing benefits. This characteristichas been shown to be a very strong compliment to Ostarine (MK-2866) and Nutrobal (MK677) in a healing protocol.
Many view LGD as the strongest and most anabolic SARM in existence. LGD can add large amounts of size without carrying the dangers and potential side effects associated with steroid use.
(LGD-4033) does come with side effects, although they have been shown by studies to be minimal. Suppression from LGD-4033 can occur in minimal instances. Studies have shown this to be dose dependent but there has also been a decrease in total and free testosterone levels as well as SHBG levels. Intriguing findings through studies revealed no significant decrease in LH or FSH levels. This finding is very encouraging as it proves that although mildly suppressive, recovery will be short and sweet. LGD is non methylated and contains no toxicity. LGD does not convert to estrogen, but in rare circumstances has caused slight estrogen irritation for a few research subjects. An aromatase inhibitor should always be on hand, even if instancesare rare. As with other SARMs, a mini post cycle therapy is all that is needed, with 2-3 weeks being the expected recovery time.
Dosage:
To get the best LGD-4033 results for cutting, a dose of 3-5mg daily is recommendedn, typically for an 8 week cycle.
In order to take advantage of the very significant bulking effects of LGD4033, a dosage of 5-10mg should be taken daily for 8 weeks.
Andarine (S-4) is categorized as a SARM as well as a research chemical. S-4 was designed to treat several severe medical conditions, such as, muscle wasting, osteoporosis and benign prostatic hyptertrophy, using the non-steroidal androgen antagonist bicalutamide as a lead compound.
S-4 is an orally partial agonist for androgen receptors. Carrying this quality allows S-4 to maintain and add lean body mass. When being compared to testosterone and other forms of steroids, the advantages of SARMS, like S-4, is they do not have androgenic activity in non-skeletal muscles.
Benefits of S4 Andarine:
The best part of S-4 is the fact that it causes a drying out of the muscle and the skin surrounding it, and in turn binds very well to the androgen muscle receptors, hardening and sharpening the muscle. This means that towards the end of a cycle, it would prove to be very effective. It could possibly be used as a pre-contest hardener, combined with other muscle hardening compounds.
S4 causes significant weight loss by binding to the androgen receptors - it allows fat to be oxidised, and it displays potent nutrient partitioning affects, causing more calories to be used to build and repair muscle. In addition, it has mild anti-oestrogen qualities, and will lower oestrogen over a 4 week period. Recovery from an S-4 cycle is pretty straight easy, so despite the mild suppression, S-4 is still a very useful SARM.
S4 side effects:
Andarine (S-4) does not carry many side effects, but there is one side effect commonly associated with use. It sounds far more serious than it actually is, so a deep understanding of it is required. Many researchers often report night vision problems when using S-4. These are not permanent and only present with S-4 use. In short, a metabolite of S4 binds to the receptor in the eye, causing a yellow tint to appear when switching from dark to lighted areas, which is especially prevalent in the evenings. It is impossible to gauge if/when/how it binds and how bad the effect could be. Some barely experience it at all, while others can find it more difficult to manage.
Although these side effects are temporary, if they are still a concern, as suggested earlier, a 5-on 2-off protocol, where S-4 is used for 5 days followed by a 2 day break (then this cycle is repeated) would be the suggested research dosing method.
S-4 does not aromatize - nor do any other SARMS. S-4 has never shown any sort of estrogen elevation. Since it has slight androgenic activity, it gives the opposite effect and actually reduces any bloating present. The hardening effects S-4 provides only confirms this.
Some users have shown very slight suppression when using S4. A short, mini post cycle therapy regimen is required with use, but the recovery time is only 2-3 weeks after completion.
Dosage:
Common dosing range is 50 to 75 mg per day (divided into 3 doses taken with meals). Some recommend starting with lower doses of 25 to 50 mg per day to decrease the risk of side effects. Andarine is often cycled.
Cutting - A 50mg dosing protocol for 6-8 weeks is ideal for cutting purposes for the majority of users. However, due to the visual side effects, some running with these doses like to follow a 5 on 2 off protocol, where S4 is used for 5 days followed by a 2 day break (then this cycle is repeated).
Recomping - A dosing protocol of 50-75mg for 4-8 weeks will give good recomp effects
Strength gains and Lean mass gains - Dosing at 50mg+ for 6-8 weeks is the sweet spot for such gains.